Shyh-Yuan LEE

  • Publish Date：2026-07-09
  • Update Date：2026-07-20
  • Units：Department of Dentistry
Shyh-Yuan LEE
Shyh-Yuan LEE, Lifetime Distinguished Professor

Email: sylee@nycu.edu.tw

Phone: +886-2-2826-7235

Office Location: Room 315, Dentistry Building

Expertise: Dental Materials, Prosthodontics, Implant Dentistry, and Digital Dentistry

Laboratory: Oral Digital Imaging Laboratory
 
Current Positions
  • Lifetime Distinguished Professor, Institute of Oral Tissue Engineering and Biomaterials, National Yang Ming Chiao Tung University
  • Adjunct Attending Physician, Department of Stomatology, Taipei Veterans General Hospital
  • Adjunct Research Fellow, Department of Medical Research, Taipei City Hospital
Education:
Institution Country Field of Study Degree / Training Year
Boston University United States Dentistry (Biomaterials) PhD 1996
Boston University United States Prosthodontics Specialty Training 1994
National Yang-Ming University Republic of China (Taiwan) Dentistry Bachelor's Degree 1982
Professional Experience:
Institution Department / Unit Position Period
National Yang Ming Chiao Tung University School of Dentistry Lifetime Distinguished Professor 2024/02–Present
National Yang Ming Chiao Tung University Oral Medicine Innovation Center Director 2023/07–2026/06
National Yang Ming Chiao Tung University School of Dentistry Distinguished Professor 2017/08–2024/01
National Yang-Ming University Office of Academic Affairs Dean of Academic Affairs 2015/08–2018/07
National Yang-Ming University School of Dentistry Dean 2008/02–2014/01
National Yang-Ming University Department of Dentistry Chair 2003/08–2007/07
National Yang-Ming University Department of Dentistry Professor 2002/08–2022/07
National Yang-Ming University School of Dentistry Associate Dean 2002/08–2003/07
National Yang-Ming University Department of Dentistry Deputy Chair 1997/08–2000/07
National Yang-Ming University Department of Dentistry
 		 Associate Professor 1996/08–2002/07
Taipei Veterans General Hospital Department of Dentistry Contract Attending Physician 1996/08–2003/08
 
National Yang-Ming University Department of Dentistry Lecturer
 		 1990/08–1996/07
Taipei Veterans General Hospital Department of Dentistry Adjunct Acting Attending Physician
 		 1989/08–1992/06
 
Taipei Veterans General Hospital Department of Dentistry Chief Resident 1988/08–1989/07
Taipei Veterans General Hospital Department of Dentistry Resident
 		 1984/08–1988/07
National Yang-Ming University Department of Dentistry Teaching Assistant 1984/08–1990/07


Research Interests
The principal research areas include (1) Infrared optical coherence tomography (OCT): Using infrared light and coherence tomography, OCT can penetrate selected dental tissues and acquire signals from subgingival tooth surfaces. After computational reconstruction of their true spatial positions, the data are assembled into a three-dimensional digital model. Compared with currently available intraoral scanners, this system can capture the complete external form and finish line of a prepared tooth without gingival retraction. Integration with 3D printing enables a distinctive digital workflow for prosthesis fabrication. The system also has potential for detecting conditions that are difficult to observe from the surface, including subgingival calculus, recurrent caries, and tooth microcracks. (2) Integration of 3D printing with clinical dentistry: Applications include polymer-based printing for provisional prostheses, complete dentures, occlusal splints, and surgical guides, as well as metal printing for customized dental implants to facilitate full-mouth reconstruction in patients with severe alveolar ridge resorption who are unable to undergo conventional implant surgery. (3) Integration of metal additive manufacturing and digital-twin modeling: This approach provides customized dental implants for patients with insufficient jawbone who are not candidates for conventional implant treatment.

 
Integrated Research Projects
Project Title Funding Agency Project Period Role
Development of an Intelligent Mass-Customization System—Clear Aligners as an Example (4/4) (113-2218-E-A49-030-) NSTC 2024/06/01–2025/05/31 Principal Investigator
Development of an Intelligent Mass-Customization System—Clear Aligners as an Example (3/4) (112-2218-E-A49-028-) NSTC 2023/06/01–2024/05/31 Principal Investigator
Development of an Intelligent Mass-Customization System—Clear Aligners as an Example (2/4) (111-2218-E-A49-025-) NSTC 2022/06/01–2023/05/31 Principal Investigator
Development of an Intelligent Mass-Customization System—Clear Aligners as an Example (1/4) (110-2218-E-A49A-502-) NSTC 2021/06/01–2022/05/31 Principal Investigator
Individual Research ProjectsIndividual Research Projects
Project Title Funding Agency Project Period Role
Intelligent Assessment of Tooth Preparation for Fixed Prosthodontics Through Integration of Cross-Disciplinary Geometric Analysis and Large Language Models (1/3) (115-2314-B-A49-022) NSTC 2026/08/01–2027/07/31 Principal Investigator
Application of Custom 3D Metal-Printed Implants in Mandibular Distal-Extension Edentulous Areas (3/3) (114-2314-B-A49-002-) NSTC 2025/08/01–2026/07/31 Principal Investigator
Application of Custom 3D Metal-Printed Implants in Mandibular Distal-Extension Edentulous Areas (2/3) (113-2314-B-A49-007-) NSTC 2024/08/01–2025/07/31 Principal Investigator
Application of Custom 3D Metal-Printed Implants in Mandibular Distal-Extension Edentulous Areas (1/3) (112-2314-B-A49-017) NSTC 2023/08/01–2024/07/31 Principal Investigator
Machine Learning-Assisted Interpretation of Periodontal Intrabony Defects on Dental Radiographs (112-2314-B-075-061-MY3) NSTC 2023/08/01–2026/07/31 Co-Principal Investigator
Application of Optical Coherence Tomography to Digital Dental Impressions (3/3) (111-2314-B-A49-078-) NSTC 2022/08/01–2023/07/31 Principal Investigator
Multidimensional Material Visual Appearance Matching—Dental Materials as an Example (111-2221-E-011-140-) NSTC 2022/08/01–2023/07/31 Co-Principal Investigator
Noninvasive Minor Salivary Gland Testing for Xerostomia Diagnosis (111-2622-B-A49-003-) NSTC 2022/06/01–2023/05/31 Principal Investigator
Determination of the Optimal Threshold for Remineralization of Early Caries Using OCT (11101-62-025) Department of Health, Taipei City Government 2022/01/01–2022/12/31 Principal Investigator
Precision Medicine for Temporomandibular Joint Arthritis Using Novel Image Analysis, Stem Cells, and 3D Printing (110-2314-B-075-021-)
 		 NSTC 2021/08/01–2022/07/31 Co-Principal Investigator
Extension Program for Metal 3D Printing in Digital Dental Technology Certification Training (EX-05-25-36-110) Southern Taiwan Science Park Bureau, NSTC 2021/03/01–2022/02/28 Principal Investigator
Application of Optical Coherence Tomography to Digital Dental Impressions (2/3) (110-2314-B-A49A-548-) NSTC 2021/08/01–2022/07/31 Principal Investigator
Deep Learning Measurement of Alveolar Bone Height in Optical Coherence Tomography Images (11001-62-034) Taipei City Department of Health 2021/01/01–2021/12/31 Principal Investigator
Development of Multiphase Polarized Photography for Dental Shade Matching and Color Reproduction (110-2221-E-011-112-) NSTC 2021/08/01–2022/07/31 Co-Principal Investigator
Southern Taiwan Smart Biomedical Industry Cluster Promotion Program—3D Printing for Digital Dental Technology Certification Training (EX-08-27-47-109) Southern Taiwan Science Park Bureau, NSTC 2020/02/01–2021/01/31 Principal Investigator
Application of Optical Coherence Tomography to Digital Dental Impressions (1/3) (109-2314-B-010-011-) NSTC 2020/08/01–2021/07/31 Principal Investigator
Industry–Academia Research Projects
Project Title Funding Agency Project Period Role
Intelligent Continuous Printing and Smart Warehousing Module Yi-Ding-Zhun Digital Technology Co., Ltd. 2023/01/01–2023/12/31 Principal Investigator
Noninvasive Minor Salivary Gland Testing for Xerostomia Diagnosis Guangming Intelligent Technology Co., Ltd. 2022/06/01–2023/05/31 Principal Investigator


Technology Transfer

2018: Nano-Dispersion Technology of Metal Oxides in Resins — Transferred to Yang Ming Digital Dental Materials Co., Ltd. (MOST 106-3114-E-010-002)


Recent Publications & Patents

Selected Publications (Past Five Years)
 
  1. Liu MR, Chen H, Tsou NT, Lee SY, Lin YM. 4D Printing of TBCHA-Based Shape Memory Polymer Composites: Bioglass 45S5 Addition Improves Stability Retention and Shape Memory Performance. 2026; 11(18):27063-27082 (SCI)
  2. Chen YC, Chen L, Lai YL, Chang WT, Lee SY. AI-Driven Detection and Measurement of Keratinized Gingiva in Dental Photographs: Validation Using Reference Retainers. Journal of Clinical Periodontology, 2025; 52(7):1056-1067. (SCI)
  3. Hsu YY, Lee SY, Li CS, Wang CY, Dung SZ. Long-term stability of maxillary anterior tooth-implant supported fixed prostheses: A 14-year case report. Journal of Dental Sciences, 2025; 20(4):2544-6. (SCI)
  4. Lu YH, Lin YM, Lee SY, Chen H High- Performance biocompatible shape memory polymers for 4D Printing: Effects of 4-tert-Butylcyclohexyl acrylate as a soft component monomer. European Polymer Journal, 2025; 238(24):114228. (SCI)
  5. Chang WT, Lyu DY, Lai YL, Yen JY, Chen YC, Lee SY. High-precision and non-invasive measurement of crestal bone level by optical coherence tomography. Journal of Dental Sciences, 2025; 20(1):147-153 (SCI)
  6. Chen H, Tang PF, Lee SY, Lin YM. Accuracy of single ceramic crowns milled on a mobile digital dental laboratory after transportation over varying distances. Journal of Dental Sciences, 2025; 20(2):1008-15 (SCI)
  7. Dung SZ, Lee SY, Tsai JS, Tzeng IS. Implants as Surveyed Crowns for Implant-Assisted Removable Partial Denture: A Long-Term Case Series Study. The International Journal of Oral & Maxillofacial Implants, 2025; 40(4):468-476 (SCI)
  8. Dung SZ, Tzeng IS, Lee SY. Maxillary posterior implant as a surveyed crown for implant-assisted removable partial denture: A case report with 10-year follow-up. Journal of Dental Sciences, 2024; 19(4):2408-2410 (SCI)
  9. Yen JY, Hsu HJ, Lai YL, I-Chiang Chou IC, Chen YC, Lee SY. Efficacy of customized crown-level position jig in measuring peri-implant crestal bone level on periapical radiographs: An in vitro study. Journal of Dental Sciences 2024; 19(1): 338-344 (SCI)
  10. Chen H, Lo WL. Lee SY, Lin YM. Controlling sintering temperature for biphasic calcium phosphate scaffolds using submicron hydroxyapatite slurries for LCD 3D printing. Ceramics International 2024; 50(7), 11060–11074 (SCI)
  11. Chen H, Lin CH, Hung SW, Lee SY, Lin YM. Effects of Acetyl Tributyl Citrate on the mechanical properties, abrasion resistance, and cytotoxicity of the light-cured 3D printing polyurethane resins. 3D Printing and Additive Manufacturing 2023; 11(6), e2014–e2021 (SCI)
  12. Wu SY, Wu CY, Lin LY, Chen Yh, Huang HY, Lai YL, Lee SY. Systemic antibiotics adjuvants to scaling and root planing in type 2 diabetic and periodontitis individuals: Systematic review with network meta-analysis. Japanese Dental Science Review 2023; 59:167-178 (SCI).
  13. Chen YC, Lai YL, Yen JY, Lin YC, Chen HH, Lee SY. Long-term evaluation of peri-implant keratinized mucosa stability after free epithelialized graft and keratinized mucosa shifting procedures: A retrospective study up to 13 years. Clinical Oral Implants Research 2023; 34:1083-1093 (SCI).
  14. Chen H, Hou JP, Lee SY, Lin YM. Effects of postpolymerization time and temperature on the flexural properties and hardness profile of three-dimensional printed provisional resin. Journal of Dental Sciences 2024; 19(1):455-460 (SCI)
  15. Yen JY, Kang L, Chou IC, Lai YL, Lee SY. Risk assessment of interproximal contact loss between implant-supported fixed prostheses and adjacent teeth: A retrospective radiographic study. Journal of Prosthetic Dentistry 2022; 127(1):86-92 (SCI).
  16. Hsiao TY, Ho YC, Lee SY, Sun CW. Degree of polarization uniformity for dental calculus visualization. Journal of Biophotonics 2022; 15(6): e202200011 (SCI).
  17. Siu WS, Shih YF, Lee SY, Hsu CY, Wei MJ, Wang TJ, Lin HC, Lin YL. Alterations in kinematics of temporomandibular joint associated with chronic neck pain. Journal of Oral Rehabilitation 2022; 49(9):860-871 (SCI).
  18. Hwang JF, Chou IC, Lai YL, Lee SY. Forced Eruption in esthetic zone from the prosthetic point of view: A case report. Journal of Prosthodontics and Implantology 2022; 11(1):14-22 (OI).
  19. Jiang CP, Cheng YC, Lin HW, Chang YL, Pasang T, Lee SY. Optimization of FDM 3D printing parameters for high strength PEEK using the Taguchi method and experimental validation. Rapid Prototyping Journal 2022; 28(7):28(7):1260–1271 (SCI).
  20. Lin CS, Liu LK, Lee WJ, Peng LN, Lin CP, Lee SY, Chen LK. Low masseter muscle mass is associated with frailty in community-dwelling older adults. Experimental Gerontology 2022; 15:163:111777 (SCI).
  21. Tsai ST, HO IC, Tsai JL, Yang SF, Lai YL, Lee SY. Evaluation of students' self-assessment performance in preclinical endodontic training by means of rubrics and a 3D printed model. Journal of The Formosan Medical Association 2022; 121(11):2203-2210 (SCI).
  22. Hwang JF, Chan KW, Chen HL, Lee SY. Restoration of flared incisor roots: a case report with 16 years of follow-up and review of literature. Journal of Prosthodontics and Implantology 2021; 10(1):17-25 (OI).
  23. Su JJ, Lin CS, Chen H, Lee SY, Lin YM. Biofabrication of Cell-Laden Gelatin Methacryloyl Hydrogels with Incorporation of Silanized Hydroxyapatite by Visible Light Projection. Polymers 2021; 13(14):2354 (SCI).
  24. Hsiao TY, Ho YC, Chen MR, Lee SY, Sun CW. Disease activation maps for subgingival dental calculus identification based on intelligent dental optical coherence tomography. Translational Biophotonics 2021; 3:1-10 (OI).
  25. Jiang CP, Hentihu MFR, Lee SY, Lin R. Multiresin Additive Manufacturing Process for Printing a Complete Denture and an Analysis of Accuracy. 3D Printing and Additive Manufacturing 2022; 9(6):511-519 (SCI).
  26. Huang YP, Lee SY. Deep Learning for Caries Detection using Optical Coherence Tomography. MedRXiv 2021: doi.org/10.1101/2021.05.04.21256502 (OI).
  27. Wu SY, Wu CY, Chen MH, Huang HY, Chen YH, Tsao YP, Lai YL, Lee SY. Periodontal conditions in patients with Sjogren’s syndrome: A meta-analysis. Journal of Dental Sciences 2021; 16(4):1222-1232 (SCI).

Patents
  1. Jaw motion tracking system and operating method using the same (2020) US Invention Patent (Publication No. US2010751152B2) Inventors: Liang-Yuan Zheng, Zhi-Yu Xu, Shyh-Yuan Lee, Yuan-Min Lin
  2. Three-Dimensional Printing Methods and Materials for Making Dental Products (2020) US Invention Patent (Publication No. US20180258290A1) – Patent Pending / Issuance in Progress Inventors: Yuan-Min Lin, Xuan Chen, Shyh-Yuan Lee, Pin-Ru Huang
  3. Optical Tomography Digital Impression Imaging System and Method for Use Thereof (2020) China Invention Patent (CN108135472 B) Inventors: Shyh-Yuan Lee, Zhi-Wei Lyu, Dong-Yuan Lyu, Yu-Zhen Lai
  4. Optical Tomography Digital Impression Imaging System and Method for Use Thereof (2019) US Invention Patent (US10426346B2) Inventors: Shyh-Yuan Lee, Zhi-Wei Lyu, Dong-Yuan Lyu, Yu-Zhen Lai
  5. Three-Dimensional Printing Manufacturing Method for Complete Dentures (2019) Taiwan (R.O.C.) Patent No. I679102 Inventors: Zhuo-Pei Jiang, Huang-Zhan Xu, Shyh-Yuan Lee, Zong-Han Lin
  6. Jaw Motion Tracking System and Method for Use Thereof (2019) Taiwan (R.O.C.) Invention Patent No. I630904 Inventors: Liang-Yuan Zheng, Zhi-Yu Xu, Shyh-Yuan Lee, Yuan-Min Lin
  7. Biodegradable Photopolymerizable Composition for Three-Dimensional Printing (2019) Taiwan (R.O.C.) Invention Patent No. I654246 Inventors: Yuan-Min Lin, Zhuo-Pei Jiang, Shyh-Yuan Lee, Xian-Da Lin
  8. Dental Materials for Three-Dimensional Printing and Preparation Method and Application Thereof (2018) Taiwan (R.O.C.) Invention Patent No. I630244 Inventors: Yuan-Min Lin, Xuan Chen, Shyh-Yuan Lee, Pin-Ru Huang
  9. Photocuring Biodegradable Polymer and Preparation Method Thereof (2018) Taiwan (R.O.C.) Invention Patent No. I614280 Inventors: Yuan-Min Lin, Zhuo-Pei Jiang, Shyh-Yuan Lee, Pin-Ru Huang
  10. Optical Tomography Digital Impression Imaging System and Method for Use Thereof (2017) Taiwan (R.O.C.) Invention Patent No. I592145 Inventors: Shyh-Yuan Lee, Zhi-Wei Lyu, Dong-Yuan Lyu, Yu-Zhen Lai
  11. System and Method for Detecting Bone Defects (2017) US Invention Patent No. US 9788749 Inventors: Min-Chun Pan, Da-Cheng Xie, Jin-Song Chen, Shyh-Yuan Lee
  12. Three-Dimensional Printing Method with Multi-Material Capability (2016) Taiwan (R.O.C.) Invention Patent No. I561369 Inventors: Zhuo-Pei Jiang, Huang-Zhan Xu, Shyh-Yuan Lee
  13. Bone Defect Detection System, Device, and Method Thereof (2016) Taiwan (R.O.C.) Invention Patent No. I546060 Inventors: Min-Chun Pan, Da-Cheng Xie, Jin-Song Chen, Shyh-Yuan Lee
  14. Method for Imaging Dental Calculus (2015) Taiwan (R.O.C.) Invention Patent No. I481392 Inventors: Shyh-Yuan Lee, Chia-Wei Sun, Yi-Ching Ho, Yao-Sheng Xie, Jing-Cheng Zhuang
  15. Irregular Bone Defect Detection Device of Dental Implant and Method Thereof (2012) Taiwan (R.O.C.) Invention Patent No. I365736 Inventors: Min-Chun Pan, Han-Bo Zhuang, Shyh-Yuan Lee
  16. Apparatus and Method of Irregular Bone Defect Detection of Dental Implant (2012) US Invention Patent No. US 8,167,614 Inventors: Min-Chun Pan, Han-Bo Zhuang, Shyh-Yuan Lee
Recent Awards and Honors
2024    Lifetime Distinguished Professor, National Yang Ming Chiao Tung University
2023    Academic Contribution Award, Chinese Dental Association
2022    Outstanding Teaching Faculty Award, Taiwan Dental Association
2021    Silver Award, Medical Device Category, 20th Pharmaceutical Technology Research and Development Award, Ministry of Economic Affairs / Ministry of Health and Welfare
2021    Best Teaching Attending Physician, Taipei Veterans General Hospital
2021    Outstanding Startup Enterprise Award, Small and Medium Enterprise Administration, Ministry of Economic Affairs
2021    Outstanding Project, Ministry of Education Teaching Practice Research Program — Application of Standardized 3D-Printed Models in Preclinical Training
2020    17th National Innovation Award, Innovative Medical Devices and Diagnostic Technology Category
2019    First Prize, Physician Innovation and Improvement Award, Taipei Veterans General Hospital
2019    First Prize, Medical Technology Innovation Award for Major Achievements, Taipei Veterans General Hospital 60th Anniversary
2018    On-Site Exhibition Award, Innovation and Invention Pavilion
 
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