Ting-Han CHANG

  • Publish Date：2026-07-14
  • Update Date：2026-07-15
  • Units：College of Dentistry
THC
Ting-Han CHANG, Assistant Professor

Tel: (+886)-2-2826-7224
Fax: (+886)-2-2826-4053
E-mail: cth0616@nycu.edu.tw
Lab web:Web link

Fields of Specialty:
Odontogenic Tumor, Stem Cell Biology, Organoid, Animal Model




Affiliations
  1. Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan
  2. Department of Dentistry, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan
Faculty Appointments
02/24 -             Assistant Professor, Institute of Oral Biology, School of Dentistry, National Yang-Ming University. Taipei, Taiwan
02/21- 01/24    Assistant Professor, Department of Dentistry, School of Dentistry, National Yang-Ming University. Taipei, Taiwan

Education
07/16-05/20     DScD, Dental Medicine, University of Pennsylvania, USA
09/02-06/08     DDS, Chung Shan Medical University, Taiwan

Fellowship Appointment
2022 -       Fellow of the Higher Education Academy (FHEA)
2017 -       Member of International Association for Dental Research/American Association for Dental Research
2014 -       Member of Taiwan Academy of Facial Plastic and Reconstructive Surgery
2012 -       Member of ITI International Team for Implantology
2008 -       Member of Association of Oral and Maxillofacial Surgery, Taiwan
2008 -       Member of Dental Science Association, Taiwan

Honors
  1. 2025 Outstanding Teacher Award, Taiwan Dental Association
  2. 2024 Distinguished Teaching Award, National Yang Ming Chiao Tung University
  3. 2023 20th National Innovation Award, Taiwan
  4. 2022 Fellow of the Higher Education Academy (FHEA)
Research Description
    My research focuses on odontogenic tumors, particularly ameloblastoma—a locally aggressive benign tumor. Our previous work identified LGR5⁺ ameloblastoma epithelial stem-like cells as contributors to resistance against BRAFV600E-targeted therapies. To further investigate the tumor microenvironment, we performed single-cell ATAC-seq and RNA-seq analyses, aiming to identify specific molecular targets. In addition, we have established ameloblastoma organoids and orthotopic mouse models to study molecular mechanisms in depth and to conduct preclinical drug testing. Our ultimate goal is to develop a drug screening platform and identify novel therapies for clinical trials, with the aim of advancing personalized precision treatment for patients.
  • Precision medicine in odontogenic and head and neck tumors
  • Stem cell regeneration in dentistry

Research Projects/Grants
  1. Tumor microenvironment regulation of LGR5 stem-like cells in Ameloblastoma/ NSTC 110-2314-B-A49A-553-MY3
  2. Investigation and Target Exosomal MicroRNAs in Ameloblastoma Microenvironment/ NSTC 113-2314-B-A49-021
  3. Investigation the Molecular Mechanism of Ameloblastoma by Targeting Activin A - New Preclinical Orthotopic Animal Model and Translational Medicine Research/ NSTC 114-2314-B-A49-035
Key Publications
  1. Hsiu-An Hsu, Da-Yo Yuh, Jonathan Jaime G. Guerrero, Wan-Chun Li, Ting-Han Chang (2026, Feb). Cone-beam computed tomography or computed tomography as an alternative diagnostic tool for temporomandibular joint disc displacement when magnetic resonance imaging is unavailable: a systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery, 55, 845–855. (SCI, 58/165, DENTISTRY, ORAL SURGERY & MEDICINE).
  2. Ting-Han Chang, Hsin-Han Hou, Yi-Shing Shieh, Her-Hsiung Huang, Da-Yo Yuh (2026, Jan). Laser-modified titanium surfaces induce sex-dimorphic secretion of angiogenic factors by gingiva-derived mesenchymal stromal cells. Journal of Dental Sciences, 21(1), 443-456. (SCI, 31/165, DENTISTRY, ORAL SURGERY & MEDICINE). NSTC 110-2314-B-A49A-553-MY3.
  3. Ting-Han Chang, Rabie M. Shanti, Yanfang Liang, Jincheng Zeng, Shihong Shi, Faizan Alawi, Lee Carrasco, Qunzhou Zhang, and Anh D. Le (2020, May). LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma. Cell Death & Disease. (IF: 8.469), 11(5):338. (SCI, 37/195, Cell Biology).  
  4. Chunmiao Jiang, Qunzhou Zhang, Rabie M. Shanti, Shihong Shi, Ting-Han Chang, Lee Carrasco, Faizan Alawi, Anh D. Le. (2017, Sep). Mesenchymal Stromal Cell-derived IL-6 Promotes Epithelial-mesenchymal Transition and Acquisition of Epithelial Stem-like Cell Properties in Ameloblastoma Epithelial Cells. Stem Cells. (IF: 6.277), 5(9):2083-2094. (SCI, 58/195, CELL BIOLOGY).
  5. Qilin Xu, Akihiro Furuhashi, Qunzhou Zhang, Chunmiao Jiang, Ting-Han Chang, and Anh D. Le. (2017, Aug). Induction of Salivary Gland–Like Cells from Dental Follicle Epithelial Cells. Journal of Dental Research. (IF: 6.116), 96(9):1035-1043. (SCI, 2/150, DENTISTRY, ORAL SURGERY & MEDICINE).
  6. Ting-Han Chang, Da-Yo Yuh, Yung-Tsan Wu, Wan-Chien Cheng, Fu-Gong Lin, Yi-Shing Shieh, Earl Fu, Ren-Yeong Huang (2015, Nov). The association between temporomandibular disorders and joint hypermobility syndrome: a nationwide population-based study. Clinical Oral Investigations, 19(8):2123-32. (SCI, 21/91, DENTISTRY, ORAL SURGERY & MEDICINE).
  7. Da-Yo Yuh, Ting-Han Chang, Ren-Yeong Huang, Wu-Chien Chien, Fu-Gong Lin, Earl Fu. (2014, Oct). The National-Scale Cohort Study on Bisphosphonate-Related Osteonecrosis of the Jaw in Taiwan. Journal of Dentistry, 42(10):1343-52. (SCI, 8/150, DENTISTRY, ORAL SURGERY & MEDICINE).
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