{"subject":"SHU-CHUN LIN","pubUnitName":"College of Dentistry","posterDate":"2026-07-14","updateDate":"2026-07-15","detailContent":"
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\"Shu-Chun
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Shu-Chun Lin, Professor
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\r\nTel: (+886)-2-2826-7272
\r\nFax: (+886)-2-2826-4053
\r\nE-mail: shuchun@nycu.edu.tw
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\r\nAffiliations
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1.Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung 
\r\n   University, Taipei, Taiwan
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2.Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan
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\r\nFaculty Appointments (in chronological order)
\r\n08/23-            Distinguished Professor, Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University. Taipei, Taiwan
\r\n08/04-07/23  Professor, Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University. Taipei, Taiwan
\r\n08/10-            Adjunct Researcher, Department of Stomatology, Taipei Veterans General Hospital, Taipei, Taiwan
\r\n08/01-07/04  Associate Professor, Institute of Oral Biology, College of Dentistry, National Yang-Ming University. Taipei, Taiwan
\r\n08/97-07/01  Assistant Professor, Institute of Oral Biology, National Yang-Ming University. Taipei, Taiwan
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\r\nEducation (in chronological order)
\r\n09/90-09/95     PhD, Biochemistry, University of Illinois, Chicago, USA
\r\n09/87-07/89     MSc, Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan.
\r\n09/84-07/87     BSc, Department of Zoology, National Taiwan University, Taipei, Taiwan
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\r\nFellowship Appointment (in chronological order)
\r\n12/95 - 07/97   Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
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\r\nAdministrative Appointments (in chronological order)
\r\n08/14 – 02/18 Dean, Office of Student Affairs, National Yang-Ming University, Taipei, Taiwan.
\r\n08/12 – 07/14 Director, Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan
\r\n02/06 – 01/08 Deputy Dean, Office of Academic Affairs, National Yang-Ming University, Taipei, Taiwan.
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\r\nFields of Specialty:
\r\nTumor Biology, Molecular Biology, Biochemistry
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\r\nResearch Description:
\r\nMy research focuses on the basic and translational mechanisms of oral cancer carcinogenesis, with an emphasis on exploring the roles of miRNAs and circRNAs in promoting oral carcinogenesis and the preclinical efficacy in molecular targeting.
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\r\nResearch Projects/Grants: National Science and Technology Council (NSTC) grants
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  1. To elucidate the mechanisms and efficacies of cold atmospheric plasma-mediated suppression of oral carcinogenesis in cell and preclinical models (NSTC 113-2314-B-A49-016-MY3)
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  2. Systemic functional elucidation of FAT family members in the pathogenesis of oral cancer (NSTC 111-2314-B-A49-025-MY3)
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  3. To investigate the roles of ferroptotic suppressors in the pathogenesis and the therapies of oral carcinoma (NSTC 110-2314-B-A49A-515-MY3)
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  4. The roles of B7-H4 ligand in modulating tumorigenesis and immune evasion in oral carcinoma (NSTC 108-2314-B-010-010-MY3)
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Key Publications: (within 6 years, *: corresponding author)
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  1. Liu YC, Liu SY, Lin YC, Liu CJ, Chang KW, Lin SC* (2024, Sep). The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma. Cell Death Discovery, 10, 392.
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  2. Chang SR, Chou CH, Tu HF, Liu CJ, Chang KW*, Lin SC* (2024, May). The expression of immune co-stimulators as a prognostic predictor of head and neck squamous cell carcinomas and oral squamous cell carcinomas. Journal of Dental Sciences, 19: 1380-88.
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  3. Chou CH, Yen CH, Liu CJ, Tu HF, Lin SC*, Chang KW* (2024, Mar). The upregulation of VGF enhances the progression of oral squamous carcinoma. Cancer Cell International, 24:115.
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  4. Cheng YC, Chang, KW, Pan JH, Chen CY, Chou CH, Tu HF, Li WC, Lin SC* (2023, Nov). Cold atmospheric plasma jet irradiation decreases the survival and the expression of oncogenic miRNAs of oral carcinoma cells. International Journal of Molecular Sciences, 2023, 24, 16662
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  5. Chang SR, Chou CH, Liu CJ, Lin YC, Tu HF, Chang KW*, Lin SC* (2023, Mar). The concordant disruption of B7/CD28 immune regulators predicts the prognosis of oral carcinomas. International Journal of Molecular Sciences, 21;24(6):5931.
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  6. Lin SC, Liu CJ, Ji SH, Hung WW, Liu YC, Chang SR, Tu HF, Chang KW* (2022, Feb). The upregulation of oncogenic miRNAs in swabbed samples obtained from oral premalignant and malignant lesions. Clinical Oral Investigations, 26(2):1343-51.
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  7. Chou CH, Fan Chiang CY, Yang CC, Liu YC, Chang SR, Chang KW*, Lin SC* (2021, Oct). miR-31-NUMB cascade modulates Monocarboxylate Transporters to increase oncogenicity and lactate production of oral carcinoma cells. International Journal of Molecular Sciences, 22(21):11731.
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  8. Chang KW, Hung WW, Chou CH, Tu HF, Chang SR, Liu YC, Liu CJ, Lin SC* (2021, Aug). LncRNA MIR31HG drives oncogenicity by inhibiting the Limb-Bud and Heart Development gene (LBH) during oral carcinoma. International Journal of Molecular Sciences, 21:8383.
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  9. Chang KW, Lin CE, Tu HF, Chung HY, Chen YF, Lin SC* (2020, Dec). Establishment of a p53 null murine oral carcinoma cell line and the identification of genetic alterations associated with this carcinoma. International Journal of Molecular Sciences, 21(24): 9354.
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  10. Lin SC, Wu HL, Yeh LY, Yang CC, Kao SY, Chang KW* (2020, Dec). Activation of the miR-371/372/373 miRNA cluster enhances oncogenicity and drug resistance in oral carcinoma cells. International Journal of Molecular Sciences, 21(24): 9442.
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  11. Yeh LY, Yang CC, Wu HL, Kao SY, Liu CJ, Chen YF, Lin SC*, Chang KW* (2020, Jan). The miR-372-ZBTB7A oncogenic axis suppresses TRAIL-R2 associated drug sensitivity in oral carcinoma. Frontiers in Oncology, 10: 47.
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  12. Chen YF, Chang KW, Yang IT, Tu HF, Lin SC* (2019, Jun). Establishment of syngeneic murine model for oral cancer therapy. Oral Oncol, 95: 194-201.
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  13. Kao YY, Chen YF, Yeh LY, Chen YF, Chang KW, Liu CJ, Fan Chiang CY, Lin SC* (2019, May). MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. Cancer Letters, 456: 40-8.
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  14. Chen YF, Liu CJ, Lin LH, Chou CH, Yeh LY, Lin SC*, Chang, KW* (2019, Mar). Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models. BMC Cancer, 19 (1): 281.
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  15. Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH, Chang KW*, Lin SC* (2019, Feb). miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A. Redox Biol, 22: 101140.
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