{"subject":"Jung-Chen LIN","pubUnitName":"Institute of Oral Tissue Engineering and Biomaterials","posterDate":"2026-06-11","updateDate":"2026-07-13","detailContent":"\r\n
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\"Jung-Chen
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Assistant Professor Jung-Chen LIN
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Phone: +886-2-2826-7314
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\r\nEmail: linjungchen@nycu.edu.tw
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\r\nOffice Location: Room 313, Dentistry Building
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Discipline: Immunoengineering, Biomimetic materials, Oral Immunology, Biochemistry
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Research focus: Biomimetic biomaterials for immunoengineering and immune modulation
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Specialty: Immunology, Bioengineering, Immunotherapy and Vaccinology
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\r\nEducation and Positions
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  • Immunology　　　　　　　　　　Graduate Institute of Immunology, College of Medicine, National Taiwan University (Ph.D, 2014 Jun.)
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  • Oral Immunology and Biology　　Institute of Oral Biology, College of Dentistry, National Yang Ming Chiao Tung University (M.S., 2004 Jun.)
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\r\nMy lab turns smart biomaterials into immune sidekicks. We gel dendritic cells from the inside, tune their stiffness to “coach” T cells, and even hydrogel-wrap nasty oral pathogens to study (and silence) them.
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\r\n(Present - 2019)
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  1. Hsu, C.Y., Tsai, P.C., Lin, J.C., Pai, C.H., Teng, Y.J., Yao, B.Y., Fei, C.Y., Shiau, G.H.M., Lin, L.C.W., Yang, H.C., Hu, C.M.J.*. 2025. Biomimetic Lymphocyte Capture by Polymer-Stabilized Superparamagnetic Antigen Presenting Cells Enriches Tumor-Reactive T cells and Improves Neoantigen Identification. Nat Commun 16 (1):5088 (IF=16.1; 8/134; Q1)
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  2. Baghdasaryan, O.#, Khan, S.#, Lin, J.C.＃, Lee-Kin, J., Hsu, C.Y., Hu, C.M.J.* and Tan, C.* 2024. Synthetic control of living cells by intracellular polymerization. Trends Biotechnol 42(2):241-252. (IF=17.3; 3/158; Q1)
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  3. Lin, C.L.; Fang, Z.S.; Hsu, C.Y.; Liu, Y.H.; Lin, J.C.; Yao, B.Y.; Li, F.A.; Yen, S.C.; Chang, Y.C., and Hu, C.M.J.* 2024.Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomater 173:325-335. (IF=9.7; 6/96; Q1)
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  4. Chien, C.Y.＃, Lin, J.C.＃, Huang, C.Y., Hsu, C.Y., Yang, K.C., Chattopadhyay, S., Nikoloutsos, N, Hsieh, P.C., and Hu, C.M.J.* 2023. In situ hydrogelation of cellular monolayers enables conformal iobmembrane functionalization for xeno-free feeder Substrate engineering. Adv Healthc Mater e2201708. (IF=10; 8/96; Q1)
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  5. Yang, K.C., Lin, J.C., Tsai, H.H., Hsu, C.Y., Shih, V, and Hu, C.M.J.* 2021. Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Deliv Transl Res11(4):1420-1437. (IF=5.4; 43/136; Q2)
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  6. Lin, J.C., Hsu, C.Y., Chen, J.Y., Fang, Z.S., Chen, H.W., Yao, B.Y., Shiau, G.H.M, Tsai, J.S., Gu, M., Jung, M.Y., Lee, T.Y., and Hu, C.M.J.* 2021. Facile transformation of murine and human primary dendritic cells into robust and modular artificial antigen-presenting systems by intracellular hydrogelation. Adv Mater 33 (30):2101190. (IF=29.4; 5/178; Q1)
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  7. Chattopadhyay, S, Liu, Y.H., Fang, Z.S., Lin, C.L., Lin, J.C., Yao, B.Y., and Hu, C.M.J.* 2020. Synthetic immunogenic cell death mediated by intracellular delivery of STING agonist nanoshells enhances anticancer chemo-immunotherapy.Nano Lett 20:2246-2256. (IF=10.8; 21/178; Q1)
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  8. Lin, L.C.W., Huang, C.Y., Yao, B.Y., Lin, J.C., Agrawal, A., Algaissi, A., Peng, B.H., Liu, Y.H., Huang, P.H., Juang, R.H., Chang, Y.C., Tseng, C.T., Chen, H.W., and Hu, C.M.J.* 2019. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against middle east respiratory syndrome coronavirus. Advanced Functional Materials 29(28):1807616. (IF=19; 8/178; Q1)
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  9. Lin, J.C.＃, Chien, C.Y.＃, Lin, C.L.＃, Yao, B.Y., Chen, Y.I., Liu, Y.H., Fang, Z.S., Chen, J.Y., Chen, W.Y., Lee, N.N., Chen, H.W., and Hu, C.M.J.* 2019. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun 10(1):1057. (IF=16.6; 6/73; Q1)
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\r\n(2018 - 2006)
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  1. Lin, L.C., Chattopadhyay, S, Lin J.C., and Hu, C.M.J.* 2018. Advances and opportunities in nanoparticle- and nanomaterial-based vaccines against bacterial infections. Adv Healthc Mater 7(13):e1701395. (IF=10; 8/96; Q1)
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  2. Ka, S.M., Chao, L. K., Lin, J.C., Chen, S.T., Li, W.T., Lin, C.N., Cheng, J.C., Jheng, H.L., Chen A., and Hua, K.F.* 2016. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med 91:10-24. (IF=7.4 ;43/285; Q1)
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  3. Chen, H.W., Huang, C.Y., Lin, S.Y., Fang, Z.S., Hsu, C.H., Lin, J.C., Chen, Y.I., Yao, B.Y., and Hu, C.M.J.* 2016.Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials 106:111-8. (IF=14; 4/96; Q1)
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  4. Ka, S.M., Lin, J.C., Lin, T.J., Liu, F.C., Chao, L.K., Ho, C.L., Yeh, L.T., Sytwu ,H.K., Hua, K.F., Chen, A.* 2015. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther 17:331. (IF=4.9; 12/34; Q2)
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  5. Lin, J.C., Lin, S.C., Chen, W.Y., Yen, Y.T., Lai, C.W., Tao, M.H., Lin, Y.L., Miaw. S.C., and Wu-Hsieh, B.A.* 2014.Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development. J Immunol 193:1258-67. (IF=4.4; 77/161; Q2)
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  6. Chang, L.Y., Lin, J.C., Chang, C.W., Ho, W.H., Chen, Y.T., Peng, J.L., and Hung, S.L.* 2009. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species, and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. J Periodontol 80:1330-7. (IF=4.3; 12/91; Q1)
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  7. Chen, D.C., Lee, Y.Y., Yeh, P.Y., Lin, J.C., Chen, Y.L., and Hung, S.L.* 2008. Eugenol inhibited the antimicrobial functions of neutrophils. J Endod 34:176-80. (IF=4.2; 14/91; Q1)
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  8. Lai, Y.L., Lin, J.C., Yang,S.F., Liu, T.Y., and Hung, S.L.* 2007. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodontal Res 42:69-76. (IF=3.5; 26/91; Q2)
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  9. Shui, H.A., Ka, S.M., Lin, J.C., Lee, J.H., Jin, J.S., Lin ,Y.F., Sheu, L.F., and Chen, A.* 2006. Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model. Nephrol Dial Transplant 21:1794-802. (IF=6.1; 4/26; Q1)
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\r\nGrant Activity
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\r\nIndividual Research Projects (as a Project Director/ Project Principal Investigator)\r\n\r\n
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  1. Development of mechano-activation to enhance T cell function via modular rigidification of intracellularly polymerized dendritic cells (114-2320-B-A49-006-MY3, 2025.01-2027.12)
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\r\nIndividual Research Projects (as a Project Co-Principal Investigator)\r\n\r\n
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  1. Dissecting the impact of facultative anaerobes and obligate anaerobes on oral epithelial cells and osteoblasts using intracellular hydrogel technology (114-2314-B-A49-027-MY2, 2025.08-2027.07)
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  2. Targeting resistance-associated metabolic and molecular cues to facilitate chemo/radio therapeutic sensitivity in oral cancers  (114-2314-B-A49-026-, 2025.08-2026.07)
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\r\nEditor, figure designer, and wrote mentoring plan (as a Postdoctoral Researcher)\r\n\r\n
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  1. mRNA vaccine enhancement strategy via nanoparticle-mediated innate immunity coordination (2022.08-2024.7)
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  2. Development and optimization of personalized nanoparticle anti-cancer vaccine (2019.08-2022.07)
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  3. The development of adjuvant-loaded nanocarriers for influenza virus vaccines (2016.08-2019.10)
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\r\nHonors/ Awards
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\r\n2023 The 33th Wang Ming-Ning Medical and Pharmaceutical Research Award-Outstanding PhD Dissertation Award—awarded by Wang Ming-Ning Memorial Foundation
\r\n2023  Poster Outstanding Awards—awarded by The 6th International Symposium of Materials on Regenerative Medicine & Annual Meeting of Biomaterials and Control Released Society in Taiwan
\r\n2022 Post-doctoral Researcher Academic Research Award—awarded by Ministry of Science and Technology
\r\n2014 Post-graduate Excellent Research Award—awarded by College of Medicine, National Taiwan University.
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\r\nPatents
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\r\nInternally fixed lipid vesicle (I653990, Taiwan)    2019/03/21
\r\nPeptide-loaded carrier system and uses thereof (PCT/US2020/043963)    2021/02/04
\r\nMethod for natural killer cell expansion (I784426, Taiwan)    2022/11/21
\r\nArtificial antigen presenting cell system and uses thereof (TW202208618A)
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\r\nTechnology Transfer
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\r\nArtificial antigen presenting cell system and uses thereof (Celtec Inc.)    2020/08/21
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\r\nConference Presentation
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  1. Chung-Yao Hsu, Jung-Chen Lin, Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Aug). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023
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  2. Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Chung-Yao Hsu, Jui-Yi Chen, Bing-Yu Yao, Yu- Han Liu, Zih-Syun Fang, Hui-Wen Chen, Che-Ming J. Hu (2023, Aug). Gelated cells as a robust cell-mimicking biomaterial system for cancer immunotherapy and tissue engineering. ISOMRM & BCRS Aug. 31 – Sep. 3 2023, Taipei, Taiwan 2023
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  3. Chung-Yao Hsu, Jung-Chen Lin, Gwo Harn Max Shiau, Bing-Yu Yao, Che-Ming Jack Hu (2023, Jul). Polymerized magnetic cells amenable to synapse formation enable selective capture of antigen-specific T lymphocytes.
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  4. Gwo Harn M Shiau, Jeng Fong Chiou, Long-Sheng Lu, Shian Ying Sung, Yin-Ju Chen, Jung-Chen Lin, Chung-Yao Hsu, Che-Ming J. Hu (2023, Jul). Unbiased T cell expansion by cancer taxidermy. 
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  5. Chung-Yao Hsu, Lung-Chen Lin and Che-Ming Jack Hu (2022, Jul). Enabling antigen-specific T cell isolation via active cellular engagement with gelated cellular systems.
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  6. Chung-Yao Hsu, Lung-Chen Lin, Wei-Li Liao, Vicky Shih, Che-Ming Jack Hu (2020, Nov). Facile hydrogelation of dendritic cells for rigidity-dependent immune modulation.
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  7. Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Dec). Gelated dendritic cells as a robust artificial antigen presenting system for cancer immunotherapy . US-Japan Drug Delivery Symposium.
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  8. Jung-Chen Lin, Chen-Ying Chien, Chi-Long Lin, Bing-Yu Yao, Yu-Han Liu, Zih-Syun Fang, Hui-Wen Chen and Che-Ming J. Hu (2019, Mar). Preparation of Stable and Effective Artificial Antigen Presenting Cells by Intracellular Hydrogelation .
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  9. Jung-Chen Lin, Shih-Ching Lin, Wen-Yu Chen, Yu-Ting Yen Chin-Wen Lai, Mi-Hua Tao, Yi-Ling Lin, Shi-Chuen Miaw, Betty A. Wu-Hsieh (2015, May). Dengue Viral Protease Interaction with NF-kB Inhibitor a/b Results in Endothelial Cell Apoptosis and Hemorrhage Development.
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\r\nInvited Presentations
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